If the substrate for an enzyme catalyzed reaction contained a negative charge, which of the following amino acids would most likely be present int eh active site to provide electrostatic destabilization of the ES complex? Why? A. Val B. Asp C. Arg D. Ser E. Gln

Answer

Asp and Glu would be the most likely amino acids present in the active site to provide electrostatic destabilization of the ES complex, due to their negatively charged side chains that can form ionic interactions with positively charged groups in the substrate.

Q: What is the role of the active site of an enzyme in a catalyzed reaction? A: The active site is the region of the enzyme where substrate molecules bind, undergo chemical reactions, and are released as products.
Q: Which amino acid side chains can form ionic interactions? A: Arg, Asp, and Glu have negatively charged side chains and can form ionic interactions with positively charged groups. Arg has a positively charged side chain and can form ionic interactions with negatively charged groups.
Q: Which amino acid(s) would be most likely to be present in the active site to provide electrostatic destabilization of the ES complex? A: Asp and Glu are negatively charged, and would be the most likely candidates to provide electrostatic destabilization of a negatively charged substrate in the ES complex.